Plasma oxysterols: Altered level of plasma 24-hydroxycholesterol in patients with bipolar disorder

Cholesterol and its oxygenated metabolites, including oxysterols, are intensively investigated as potential players in the pathophysiology of brain disorders. Altered oxysterol levels have been described patients with numerous neuropsychiatric Recent studies shown that Bipolar disorder (BD) is associated disruption cholesterol metabolism. The present study was aimed at investigating profile oxysterols plasma, their ratio to total association clinical parameters BD. Thirty three men diagnosed BD forty healthy controls matched for age sex were included study. Oxysterol measured by isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry. Significantly higher observed cholestane-3?,5?,6?-triol, 27-hydroxycholesterol (27?OHC) Cholestanol concentration 24-hydroxycholesterol (24?OHC) significantly lower compared controls. 24?OHC also negatively correlated MAS subscale score (r =-0.343; p = 0.049). In patients, inversely -0.240; 0.045). Multivariate analysis found acute decompensation independently related rise plasma (p 0.002; OR 0.966, 95 % CI [0.945 – 0.987]). However, assay relevance a biomarker this disease deserves further investigation other studies.